Richard (1969) (32K)

Frederik Marinus August van Schaik


Born 16-06-1957 at Amsterdam
From 1-9-1978 onwards Technician at Physiological Chemistry Utrecht
First a temporary appointment via ZWO (Pure Scientific research, now-a-days called SON see NWO)
Afterwards via the University of Utrecht
And lately via University Medical Center Utrecht (UMCU)
Employed with:
    Prof. Dr. H.Th.M. Timmers (2001-present)
    Prof. Dr. Ir. J.S. Sussenbach (1997-2001)
    Prof. Dr. P.C. van der Vliet (1996-1997)
    Prof. Dr. Ir. J.S. Sussenbach (1978-1995)
    Prof. Dr. H.J. Nijkamp (1976-1978) (Learning technician at the Free University of Amsterdam)
Co-author of (retrieved via PubMed):
    J Biomol Screen. 2014 Feb;19(2):287-96. doi: 10.1177/1087057113515024. Epub 2013 Dec 11. A novel microscopy-based high-throughput screening method to identify proteins that regulate global histone modification levels. Baas R, Lelieveld D, van Teeffelen H, Lijnzaad P, Castelijns B, van Schaik FM, Vermeulen M, Egan DA, Timmers HT, de Graaf P.
    Epigenetics & Chromatin 2013 May; 6(1):12. Nucleosomal DNA binding drives the recognition of H3K36-methylated nucleosomes by the PSIP1-PWWP domain. Rick van Nuland, Frederik Ma van Schaik, Marieke Simonis, Sebastiaan van Heesch, Edwin Cuppen, Rolf Boelens, Ht Marc Timmers, Hugo van Ingen.
    PLoS ONE 01/2013; 8(9):e73495. Multivalent Engagement of TFIID to Nucleosomes. Rick van Nuland, Andrea W Schram, Frederik M A van Schaik, Pascal W T C Jansen, Michiel Vermeulen, H T Marc Timmers.
    EMBO J. 2010 29, 3967-3978. A phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes. Radhika A. Varier, Nikolay S. Outchkourov, Petra de Graaf, Frederik M.A. van Schaik, Henk Jan Ensing, Fangwei Wang, Jonathan M. G. Higgins, Geert J.P.L. Kops and H.Th. Marc Timmers.
    Mol. Cell. Biol. 2010 13, 3286-3298. PHF8 targets histone methylation and RNA polymerase II to activate transcription. Klaus Fortschegger, Petra de Graaf, Nikolay S. Outchkourov, Frederik M.A. van Schaik, H.Th. Marc Timmers and Ramin Shiekhattar.
    Biochemical J. 2009 422, 443-453. Human Ccr4-Not complexes contain variable deadenylase subunits. Nga-Chi Lau, Annemieke Kolkman, Frederik M.A. van Schaik, Klaas W. Mulder, W.W.M. Pim Pijnappel, Albert J. Heck, H.Th. Marc Timmers.
    Structure, Vol 16, 1245-1256, 06 August 2008. Structural Insight into the Recognition of the H3K4me3 Mark by the TFIID Subunit TAF3. Hugo van Ingen, Frederik M.A. van Schaik, Hans Wienk, Joost Ballering, Holger Rehmann, Annemarie C. Dechesne, John A.W. Kruijzer, Rob M.J. Liskamp, H.Th. Marc Timmers, and Rolf Boelens.
    Cell. 2007 Oct 5;131(1):58-69. Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4. Vermeulen M, Mulder KW, Denissov S, Pijnappel WW, van Schaik FM, Varier RA, Baltissen MP, Stunnenberg HG, Mann M, Timmers HT.
    Biochemical J. 2006 398, 461-467. Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex. Sandrine Jayne, Carin G.M. Zwartjes, Frederik M.A. van Schaik, H.Th.Marc Timmers
    Nucleic Acids Research, 2005, Vol. 33, No. 17 Mutational analysis of BTAF1–TBP interaction: BTAF1 can rescue DNA-binding defective TBP mutants Marcin P. Klejman, Xuemei Zhao, Frederik M. A. van Schaik, Winship Herr and H. Th. Marc Timmers
    J Mol Biol 2004 Sep 20;344:513-26 Solution structure of the ubiquitin-conjugating enzyme UbcH5B. Klaartje Houben; Cyril Dominguez, Dr; Frederik M.A. van Schaik; H.Th. Marc Timmers, Dr; Alexandre M.J.J. Bonvin, Dr; Rolf Boelens, Dr
    Structure 2004 Apr;12:633-44 Structural Model of the UbcH5B/CNOT4 Complex Revealed by Combining NMR, Mutagenesis, and Docking Approaches. Cyril Dominguez, Alexandre M.J.J. Bonvin, G. Sebastiaan Winkler, Frederik M.A. van Schaik, H.Th. Marc Timmers, and Rolf Boelens.
    Cancer Cell International 2003, 3:10 (11 Jul 2003) Estradiol responsiveness of MCF-7 laboratory strains is dependent on an autocrine signal activating the IGF type I receptor. Irene HL Hamelers, Richard FMA van Schaik, John S Sussenbach and Paul H Steenbergh.
    J Biol Chem 2002 Dec 6;277(49):47645-47652 Insulin-like Growth Factor I Triggers Nuclear Accumulation of Cyclin D1 in MCF-7S Breast Cancer Cells. Hamelers IH, Van Schaik RF, Sipkema J, Sussenbach JS, Steenbergh PH.
    Exp Cell Res 2002 Feb 1;273(1):107-17 Synergistic proliferative action of insulin-like growth factor I and 17 beta-estradiol in MCF-7S breast tumor cells. Hamelers IH, van Schaik RF, van Teeffelen HA, Sussenbach JS, Steenbergh PH.
    J Mol Biol 1998 Feb 20;276(2):367-77 High-affinity DNA binding by the C-terminal domain of the transcriptional coactivator PC4 requires simultaneous interaction with two opposing unpaired strands and results in helix destabilization. Werten S, Langen FW, van Schaik R, Timmers HT, Meisterernst M, van der Vliet PC.
    J Biol Chem 1997 Dec 5;272(49):31163-71 Mitogenic signaling of insulin-like growth factor I in MCF-7 human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen-activated protein kinase. Dufourny B, Alblas J, van Teeffelen HA, van Schaik FM, van der Burg B, Steenbergh PH, Sussenbach JS.
    J Biol Chem 1995 Jan 20;270(3):1068-73 The promoter of the salmon insulin-like growth factor I gene is activated by hepatocyte nuclear factor 1. Kulik VP, Kavsan VM, van Schaik FM, Nolten LA, Steenbergh PH, Sussenbach JS.
    Mol Endocrinol 1994 Dec;8(12):1636-45 Expression of the insulin-like growth factor I gene is stimulated by the liver-enriched transcription factors C/EBP alpha and LAP. Nolten LA, van Schaik FM, Steenbergh PH, Sussenbach JS.
    Mol Reprod Dev 1993 Aug;35(4):365-7 Functional analysis of the human IGF-I gene promoters. Steenbergh PH, Jansen E, van Schaik FM, Sussenbach JS.
    Biochem Biophys Res Commun 1992 Sep 30;187(3):1219-26 The human IGF-I gene contains two cell type-specifically regulated promoters. Jansen E, Steenbergh PH, van Schaik FM, Sussenbach JS.
    Mol Cell Endocrinol 1991 Oct;81(1-3):81-94 Initial characterization of the four promoters of the human insulin-like growth factor II gene. van Dijk MA, van Schaik FM, Bootsma HJ, Holthuizen P, Sussenbach JS.
    Biochim Biophys Acta 1988 Sep 7;950(3):282-95 Differential expression of the human insulin-like growth factor II gene. Characterization of the IGF-II mRNAs and an mRNA encoding a putative IGF-II-associated protein. de Pagter-Holthuizen P, Jansen M, van der Kammen RA, van Schaik FM, Sussenbach JS.
    FEBS Lett 1987 Apr 20;214(2):259-64 The human insulin-like growth factor II gene contains two development-specific promoters. de Pagter-Holthuizen P, Jansen M, van Schaik FM, van der Kammen R, Oosterwijk C, Van den Brande JL, Sussenbach JS.
    Horm Res 1986;24(2-3):131-40 Molecular aspects of the human somatomedins. Van den Brande JL, Jansen M, Hoogerbrugge CM, de Pagter-Holthuizen P, van Buul-Offers SC, van Schaik FM, Sussenbach JS.
    FEBS Lett 1986 Jan 20;195(1-2):179-84 Organization of the human genes for insulin-like growth factors I and II. de Pagter-Holthuizen P, van Schaik FM, Verduijn GM, van Ommen GJ, Bouma BN, Jansen M, Sussenbach JS.
    FEBS Lett 1985 Jan 7;179(2):243-6 Nucleotide sequences of cDNAs encoding precursors of human insulin-like growth factor II (IGF-II) and an IGF-II variant. Jansen M, van Schaik FM, van Tol H, Van den Brande JL, Sussenbach JS.
    Nature 1983 Dec 8-14;306(5943):609-11 Sequence of cDNA encoding human insulin-like growth factor I precursor. Jansen M, van Schaik FM, Ricker AT, Bullock B, Woods DE, Gabbay KH, Nussbaum AL, Sussenbach JS, Van den Brande JL.
    Virology 1983 Jul 15;128(1):140-53 Structure and function of adenovirus DNA binding protein: comparison of the amino acid sequences of the Ad5 and Ad12 proteins derived from the nucleotide sequence of the corresponding genes. Kruijer W, van Schaik FM, Speijer JG, Sussenbach JS.
    Virology 1983 Jan 30;124(2):425-33 Structure and function of DNA binding proteins from revertants of adenovirus type 5 mutants with a temperature-sensitive DNA replication. Kruijer W, Nicolas JC, van Schaik FM, Sussenbach JS.
    Nucleic Acids Res 1982 Aug 11;10(15):4493-500 Nucleotide sequence of the gene encoding adenovirus type 2 DNA binding protein. Kruijer W, Van Schaik FM, Sussenbach JS.
    Nucleic Acids Res 1981 Sep 25;9(18):4439-57 Structure and organization of the gene coding for the DNA binding protein of adenovirus type 5. Kruijer W, van Schaik FM, Sussenbach JS.
    Nucleic Acids Res 1980 Dec 20;8(24):6033-42 Nucleotide sequence analysis of a region of adenovirus 5 DNA encoding a hitherto unidentified gene. Kruijer W, van Schaik FM, Sussenbach JS.
    Earlier as learning technician (in the acknowledgements, so no coauthor!)
    http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=327674 Nucleic Acids Res. 1979 January; 6(1): 71–80. Origin and direction of replication of the bacteriocinogenic plasmid Clo DF13. A R Stuitje, E Veltkamp, P J Weijers, and H J Nijkamp.

Last update 15-02-2014
Richard van Schaik